Reviews, technical notes and methodological notes on research peptides. Halfway between the paper and the popular article: rigorous, no useless jargon, with cited sources.
Research area · June 28, 2026 · 8 min read
Defensins, cathelicidins (LL-37) and magainin as templates against antibiotic resistance: membrane mechanisms, synthetic analogs, and the bottlenecks that still define preclinical AMP research.
Compound · June 28, 2026 · 8 min read
Critical synthesis of preclinical findings on BPC-157: proposed mechanisms, animal models of tendon, gut and bone injury, and the structural limitations still blocking clinical translation.
Compound · June 28, 2026 · 8 min read
Technical comparison of three GHRH analogs used in preclinical research: sermorelin, CJC-1295 no-DAC, and CJC-1295 with DAC. Half-life, receptor selectivity, and pulsatility.
Framework & methodology · June 28, 2026 · 8 min read
A practical guide to reading a peptide CoA: HPLC purity, observed vs theoretical mass, lot number, storage conditions, and why citing the LOT in publications is non-negotiable.
Research area · June 28, 2026 · 8 min read
How bioactive fragments of the extracellular matrix — matrikines such as VGVAPG, GHK, GFOGER and QHREDGS — signal to fibroblasts, keratinocytes and endothelial cells in preclinical models.
Background science · June 28, 2026 · 8 min read
Why linear peptides fail orally, which cyclization and N-methylation strategies rescue them, and how permeability is measured in 2026.
Compound · June 28, 2026 · 8 min read
A research-focused review of the GHK copper tripeptide: coordination chemistry, fibroblast and keratinocyte signaling, and in vitro evidence on extracellular matrix remodeling. Research use only.
Research area · June 28, 2026 · 8 min read
A scientific overview of GHRH analogs and GHS-R1a agonists (ghrelin mimetics): what sets them apart, what preclinical evidence supports, and why it matters for 2026 research.
Background science · June 28, 2026 · 8 min read
How peptide HPLC purity is calculated, what 95%, 98% and 99% actually mean for research work, and why a high number does not guarantee a biologically clean material.
Framework & methodology · June 28, 2026 · 8 min read
A practical guide to the 2D and 3D cell models most used for peptide screening, which assays match which biological question, and where they break when extrapolating to in vivo.
Research area · June 28, 2026 · 8 min read
Bibliographic review of IGF-1 analogues and insulin-mimetic fragments as in vitro tools for dissecting the PI3K/Akt and MAPK pathways in HepG2, C2C12 and MCF-7 lines.
Background science · June 28, 2026 · 8 min read
How ESI-MS and MALDI-TOF confirm a synthetic peptide's identity and sequence, what multiply charged peaks really mean, and how to read the MS section of a CoA without getting lost.
Compound · June 28, 2026 · 8 min read
Two α-MSH-derived peptides with opposite pharmacological profiles: Melanotan II as a pan-melanocortin agonist and PT-141 as an MC4R-biased ligand. A review of mechanisms and preclinical evidence.
Background science · June 28, 2026 · 8 min read
Why research peptides ship as freeze-dried cakes, what mannitol and trehalose actually do, and how reconstitution and storage choices shape molecular integrity.
Framework & methodology · June 28, 2026 · 8 min read
A practical guide to telling a solid paper from a weak one when researching peptides: peer review, evidence hierarchy, basic statistics, conflicts of interest, and why Reddit is not a source.
Framework & methodology · June 28, 2026 · 8 min read
What actually degrades a peptide in water, how long a reconstituted vial really lasts, and which pH, temperature, and additive choices move the experimental outcome.
Framework & methodology · June 28, 2026 · 8 min read
What RUO means under 21 CFR 809.10, how it differs from IUO and GMP-grade material, and why a serious research-peptide supplier never publishes human dosing protocols.
Background science · June 28, 2026 · 8 min read
A walkthrough of solid-phase peptide synthesis: Fmoc vs Boc strategies, resin choice, coupling chemistry, TFA cleavage and preparative HPLC purification.
Compound · June 28, 2026 · 8 min read
Structural and functional differences between endogenous thymosin β4 and the synthetic TB-500 fragment. Mechanisms, preclinical evidence, and why it matters for 2026 research.
Research area · June 28, 2026 · 8 min read
Self-assembling peptides, RGD, IKVAV and VGVAPG motifs: how short peptides became the modular building block of regenerative scaffolds over the last decade.